Oncolytic Viruses: The Best is Yet to Come
Oncolytic viruses are a promising anti-cancer platform, achieving significant pre-clinical and clinical milestones in recent years. A full arsenal of selective, safe, and effective viruses has been...
View ArticleAutophagy Inhibition in Childhood Nephroblastoma and the Therapeutic...
Background: Autophagy is a physiological pathway characterized by lysosomedependent self-digestion to recycle damaged or superfluous cellular content. Deregulation of autophagy hampers the maintenance...
View ArticleHIF1A is Overexpressed in Medulloblastoma and its Inhibition Reduces...
Background: Genetic and epigenetic modifications are closely related to tumor initiation and progression and can provide guidance for understanding tumor functioning, potentially leading to the...
View ArticleEffects of PHA-665752 and Cetuximab Combination Treatment on In Vitro and...
Background: It remains unknown whether blockade of c-Met signaling and epidermal growth factor receptor signaling is effective in suppressing the growth of human colorectal cancer (CRC) cells. In this...
View ArticleMicroRNA Key to Angiogenesis Regulation: MiRNA Biology and Therapy
Angiogenesis is involved in maintaining normal physiological processes like embryonic development, wound healing, inflammation and reproduction. Pathogenesis of various diseases like diabetic...
View ArticleThe Complexity of DEK Signaling in Cancer Progression
The DNA binding protein and chromatin structural regulator DEK regulate many cellular processes. These include proliferation, differentiation, apoptosis, senescence, DNA repairing and the maintenance...
View ArticleElaborating the Role of Natural Products on the Regulation of Autophagy and...
Autophagy is an intracellular lysosomal/vacuolar degradation system, in which the inner cytoplasmic cell membrane is degraded by the lysosomal hydrolases, followed by the resulting products released...
View ArticleObesity and Cancer: Biological Links and Treatment Implications
Obesity is an epidemic disease and correlates with cardiovascular diseases increasing the overall mortality. However, it has been recently demonstrated that cancer is an unexpected consequence of...
View ArticleTargeting STEAP1 Protein in Human Cancer: Current Trends and Future Challenges
Cancer is a global health issue that impairs the life quality of patients and origins thousands of deaths annually worldwide. Six-transmembrane epithelial antigen of the prostate (STEAP1) was...
View ArticleNeoisoliquiritigenin Inhibits Tumor Progression by Targeting GRP78-β-...
Background: Breast cancer mortality has been stable or decreasing in the world, its incidence and recurrence rates have sharply risen worldwide in the recent years. Objective: To investigate the...
View ArticleFOXP2 Promotes Tumor Proliferation and Metastasis by Targeting GRP78 in...
Background: FOXP2, a member of the forkhead box P (FOXP) family, has been reported to be important in breast cancer. However, its exact mechanisms and pathways remain unclear. Objective: To investigate...
View ArticleDNA Fragmentation, Cell Cycle Arrest, and Docking Study of Novel Bis...
Background: Recently, it is reported that heterocycles containing pyrimidoquinoline moiety show a broad spectrum of medicinal and pharmacological properties including anticancer, anti-microbial,...
View ArticleChemosensitizing Activity of Histone Deacetylases Inhibitory Cyclic...
Background: Anti-tumor effect of hydroxamic acid derivatives is largely connected with its properties as efficient inhibitors of histone deacetylases, and other metalloenzymes involved in...
View ArticleThe PI3K Pathway at the Crossroads of Cancer and the Immune System:...
Immunotherapy has led to a paradigm shift in the treatment of some malignancies, providing long-term, durable responses for a subset of patients with advanced cancers. Increasingly, research has...
View ArticleCell-derived Exosomes as Promising Carriers for Drug Delivery and Targeted...
Exosomes are small vesicles that are secreted by various types of cells, known to mediate signal transduction between cells. During recent years, novel carriers for the delivery of targeted drugs,...
View ArticleSynthetic Lethality: From Research to Precision Cancer Nanomedicine
Cancer is an evolutionary disease with multiple genetic alterations, accumulated due to chromosomal instability and/or aneuploidy and it sometimes acquires drug-resistant phenotype also. Whole genome...
View ArticleInvolvement of CD24 in Multiple Cancer Related Pathways Makes It an...
CD24 (cluster of differentiation 24) is a small heavy glycosylated protein, which is overexpressed in many cancer and some cancer stem cells and is associated with the development, invasion, and...
View Article