Targeting the HIF-1α/Cav-1 Pathway with a Chicory Extract/Daidzein...
Background: Hepatocellular carcinoma (HCC) is one of the most rapidly growing solid cancers, that is characterized by hypoxia. Hypoxia-inducible factor-1α (HIF-1α) is a transcription factor that...
View ArticleCDK-associated Cullin 1 Promotes Cell Proliferation and Inhibits Cell...
Background: Glioma is the most common intracranial primary tumour of adult humans, and its pathological mechanism and molecular characteristics are still under investigation. CDK-associated cullin 1...
View ArticleMALAT1 Promotes Tumorigenesis and Increases Cellular Sensitivity to Herceptin...
Background: The function of MALAT1, a long non-coding RNAs (lncRNA), in HER2- positive breast cancer remains largely unexplored. Objectives: This study aimed to investigate the effect of MALAT1 on...
View ArticleDDX39B Predicts Poor Survival and Associated with Clinical Benefit of...
Background: Immune checkpoint inhibitors (ICI) have been shown to improve overall survival (OS) in clear cell renal cell carcinoma (ccRCC) patients. However, less than half of the ccRCC patients have...
View ArticleA Molecular Link Between Diabetes and Breast Cancer: Therapeutic Potential of...
Female breast cancer recently surpassed lung cancer and became the most commonly diagnosed cancer worldwide. As per the recent data from WHO, breast cancer accounts for one out of every 8 cancer cases...
View ArticleMetastatic Breast Cancer, Organotropism and Therapeutics: A Review
The final stage of breast cancer involves spreading breast cancer cells to the vital organs like the brain, liver lungs and bones in the process called metastasis. Once the target organ is overtaken by...
View Article