The Novel VEGF121-VEGF165 Fusion Attenuates Angiogenesis and Drug Resistance...
Anti-angiogenesis therapy is one major approach of cancer therapies nowadays. Unfortunately, anti-angiogenesis therapy targeting VEGF-A was recently stumbled by the drugresistance that results from...
View ArticleTargeting ABCB1 and ABCC1 with their Specific Inhibitor CBT-1® can...
Clinical treatment response achievable with conventional chemotherapy in high-grade osteosarcoma (OS) is severely limited by the presence of intrinsic or acquired drug resistance, which in previous...
View ArticleExploiting HPV-Induced Carcinogenesis for a Rational Drug Development in...
Cervical carcinomas are almost universally associated with high-risk human papillomavirus (HPV) infections, and are a leading cause of cancer death in women worldwide. Since the late 1990s, when a...
View ArticleRole of Liprins in the Regulation of Tumor Cell Motility and Invasion
Invasion leading to the formation of metastasis is one of the hallmarks of cancer. Analysis of different human cancers has led to the identification of the PPFIA1 gene encoding the protein liprin-α1, a...
View ArticleUnderstanding Cancer Drug Resistance by Developing and Studying Resistant...
Despite the enormous number of anticancer drugs presently available in the clinic, treatment failure due to drug resistance is very frequent. The identification of mechanisms of resistance to different...
View ArticlePotential Therapeutic Approaches for the Treatment of Acute Myeloid Leukemia...
Background: Twenty percent of patients with Acute Myeloid Leukemia (AML) carry a translocation between chromosomes 21 and chromosome 8 resulting in the formation of a chimeric oncoprotein AML1-ETO. The...
View ArticleIs there a Place for Bevacizumab in Patients with Extensive-Stage Small Cell...
It was estimated that small cell lung cancer (SCLC) accounts for about one Sixth of all lung cancer cases. Patients with SCLC are usually diagnosed in advanced stage of disease. Unfortunately at this...
View ArticleSmall Molecules Targeting Ataxia Telangiectasia and Rad3-Related (ATR)...
The main aim of current cancer research is to find a way to selectively affect the tumor cells, while leaving normal cells intact. Ataxia telangiectasia and Rad3-related kinase (ATR), a member of the...
View ArticleEpigallocatechin-3-gallate Increases RXRγ-mediated Pro-apoptotic and...
Molecules with synergistic effects often enhance the benefits of cancer therapy. We observed that the major catechin of green tea, (-)-Epigallocatechin-3-gallate (EGCG), induced retinoid X receptor-γ...
View ArticleDevelopment of Linker-Conjugated Nanosize Lipid Vesicles: A Strategy for Cell...
Among the various drug delivery devices, nanoliposome is an emerging formulation in the treatment of cancer. Here we have developed tamoxifen citrate (TC) loaded nanoliposome conjugated with...
View ArticleAdvances in Synergistic Combinations of Chinese Herbal Medicine for the...
The complex pathology of cancer development requires correspondingly complex treatments. The traditional application of individual single-target drugs fails to sufficiently treat cancer with durable...
View ArticleNew Insights into the Molecular Resistance Mechanisms of Chronic Myeloid...
Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm characterized by the causative oncoprotein BCR-ABL1 (Breakpoint-cluster region/Abelson kinase), which is a fusion protein with...
View ArticleA New Therapeutic Era in GCB and ABC Diffuse Large B-cell Lymphom a Molecular...
In the past 15 years, advances in molecular biology have exposed the genetic and physiopathologic heterogeneity of diffuse large B-cell lymphoma (DLBCL). Subsets of patients have been identified in...
View ArticleTargeted Inhibition of Rictor/mTORC2 in Cancer Treatment: A New Era after...
The evolutionarily conserved mechanistic target of rapamycin (mTOR) forms two functionally distinct complexes, mTORC1 and mTORC2. mTORC1, consisting of mTOR, raptor, and mLST8 (GβL), is sensitive to...
View ArticleS-equol, a Secondary Metabolite of Natural Anticancer Isoflavone Daidzein,...
Forkhead box O3 (FOXO3a) is a transcription factor with tumor suppressor functions that plays an important role in prostate cancer. Daidzein, one of the soy isoflavones present in soy-based foods, has...
View ArticleComparative Proteomic Profiling of Extracellular Proteins between Normal and...
Gastric cancer is the second leading cause of cancer-related deaths worldwide. Gastric cancer is often detected at a late stage when treatment is difficult. Biomarkers for early detection and drug...
View ArticleMechanisms and Therapeutic Targets of microRNA-associated Chemoresistance in...
Epithelial ovarian cancer (EOC) is the most lethal disease among gynecologic malignancies. Despite increasing knowledge of ovarian cancer biology and advances in treatment efficacy, the survival rate...
View ArticleNab-Paclitaxel in Metastatic Breast Cancer: Defining the Best Patient Profile
Around 40% of patients with breast cancer will present with a recurrence of the disease. Chemotherapy is recommended for patients with recurrent hormone-independent or hormone-refractory breast cancer...
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