Preferentially Expressed Antigen in Melanoma (PRAME) and the PRAME Family of...
Preferentially expressed antigen in melanoma (PRAME) is the best characterized member of the PRAME family of leucine-rich repeat (LRR) proteins. Mammalian genomes contain multiple members of the PRAME...
View ArticleLactate Transporters and pH Regulation: Potential Therapeutic Targets in...
Despite advances in therapy, glioblastoma (GBM) is still the most prevalent and lethal brain tumor. Thus, it is imperative to identify new and effective therapies that could improve the lifetime of...
View ArticleMolecular Targeted Magnetic Resonance Imaging of Human Colorectal Carcinoma...
Objective: To investigate the feasibility of superparamagnetic iron oxide (SPIO) nanoparticles (SPIO) as a magnetic resonance (MR) contrast agent to enhance tumor imaging in vivo. Methods: Hydrophobic...
View ArticleNanoparticles for Colorectal Cancer Targeted Drug Delivery and MR Imaging:...
The application of nanoparticles (NPs) offers new prospects for the early detection and effective therapy of colorectal cancer (CRC). Various NPs have been designed and explored as diagnostic and/or...
View ArticlePeptides to Target Tumor Vasculature and Lymphatics for Improved...
Cancer has become one of the leading causes of increased mortality. The currently employed diagnostic and therapeutic modality offers only minimal specificity towards cancerous cells and affects normal...
View ArticleTargeted Delivery of Bleomycin: A Comprehensive Anticancer Review
Despite being one of the most effective broad-spectrum chemotherapeutic agents in the treatment of cancers, the clinical applications of bleomycins (BLMs) have been limited due to their poor drug...
View ArticleTargeting Tumors with Small Molecule Peptides
Chemotherapeutic treatment of cancers is a challenging endeavor, hindered by poor selectivity towards tumorous tissues over healthy ones. Preferentially delivering a given drug to tumor sites...
View ArticleCurrent Strategy for Cisplatin Delivery
Cisplatin is one of the leading chemotherapy drugs currently used in clinical settings. However, its serious side effects and its resistance developed by tumor cells hinder its usage. To decrease its...
View ArticleRecent Advances in Site Specific Conjugations of Antibody Drug Conjugates (ADCs)
Antibody-drug conjugates (ADCs) take the advantage of antigen specificity of monoclonal antibodies to deliver highly potent cytotoxic drugs selectively to antigen-expressing tumor cells. The recent...
View ArticleBispecific Antibodies for Targeted Delivery of Dendritic Polyglycerol (dPG)...
One approach to further improve the therapeutic efficacy of nanoparticles is employment of active targeting strategies. Bispecific antibodies (bsAbs) that bind to both tumor specific antigens on the...
View ArticlePersistent GP130/STAT3 Signaling Contributes to the Resistance of...
To test the role of STAT3 in human rhabdomyosarcoma cells, genetic approaches were used to either knockdown the expression of STAT3 and GP130, an upstream activator of STAT3 using short hairpin RNA...
View ArticleMT1-MMP Activation of TGF-β Signaling Enables Intercellular Activation of an...
Membrane type 1-matrix metalloproteinase (MT1-MMP, MMP-14) is associated with cancer invasion and metastasis leading to poor patient prognosis. MT1-MMP mediates cancer cell invasion via degradation of...
View ArticleBRCA1-Associated Triple-Negative Breast Cancer and Potential Treatment for...
Triple-negative breast cancer (TNBC) is defined by the absence of expression of estrogen receptor (ER), progesterone receptor (PR), and a lack of overexpression or amplification of human epidermal...
View ArticleRoles of Interferon Regulatory Factors in Chronic Myeloid Leukemia
The Interferon Regulatory Factor (IRF) family consists of multiple transcription factors involved in the regulation of a variety of biological processes. Originally identified as transcriptional...
View ArticleUnderstanding Molecular Pathways and Targets of Brachyury in...
Brachyury is an important transcription factor of the T-box gene family with an evolutionarily-conserved function in mesoderm development in the embryo. Recent research has demonstrated that, in...
View ArticleRBM15 Functions in Blood Diseases
RBM15, an RNA-binding protein, plays important roles in the growth and apoptosis of cells, especially blood cells through regulating multiple signal pathways such as Notch and Wnt. An increasing body...
View ArticlenMET, A New Target in Recurrent Cancer
Membranous Met is classically identified with its role in cancer metastases, while nuclear Met is associated with a more invasive, aggressive and proliferative form of cancer. Full-length Met or...
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