Protein Geranylgeranyltransferase Type 1 as a Target in Cancer
The process of protein prenylation involves the covalent linkage of either farnesyl (15-carbon) or geranylgeranyl (20-carbon) isoprenoid lipds to conserved cysteine residues in the carboxyl-terminus of...
View ArticleProteomic and Metabolic Signatures of Esophageal Squamous Cell Carcinoma
Esophageal squamous cell carcinoma (ESCC), which is the most common subtype of esophageal cancers, is the sixth leading cause of cancer deaths worldwide with a five-year survival rate of 19%....
View ArticleTherapeutic Approach to Patients with Chronic Lymphocytic Leukemia and...
Clinical trials in chronic lymphocytic leukemia (CLL) have focused mainly on younger fit patients until recently. However, CLL is a disease of elderly and many patients have significant comorbid...
View ArticleRefractory Chronic Lymphocytic Leukemia: A Therapeutic Challenge
Despite impressive therapeutic progress represented by the advent of chemoimmunotherapy, chronic lymphocytic leukemia (CLL) remains incurable by conventional modalities. Refractory CLL defined by...
View ArticleMechanistic and Clinical Aspects of Lenalidomide Treatment for Chronic...
There have been significant advances in our understanding of the pathogenesis of chronic lymphocytic leukemia (CLL) over the last decade, which has been accompanied by a rapid increase in treatment...
View ArticleTargeting Signaling Pathways in Chronic Lymphocytic Leukemia
Various signal transduction pathways have been implicated in the pathogenesis of chronic lymphocytic leukemia (CLL), which is characterized by the progressive accumulation of monoclonal CD5+ B cells in...
View ArticleFunctional and Clinical Significance of the Integrin Alpha Chain CD49d...
Chronic lymphocytic leukemia (CLL) is a clinically heterogeneous disease characterized by the accumulation/expansion of a clonal population of neoplastic cells with the morphological appearance of...
View ArticleDeregulation of Apoptosis - Is it Still an Important Issue in Pathogenesis of...
Chronic lymphocytic leukemia (CLL), a clonal expansion of B CD5+ cells, is the most common type of adult leukemia in western countries. The accumulation of neoplastic B-cells is primarily caused by...
View ArticlePyrimethamine as a Potent and Selective Inhibitor of Acute Myeloid Leukemia...
Hematopoietic stem and progenitor cell differentiation are blocked in acute myeloid leukemia (AML) resulting in cytopenias and a high risk of death. Most patients with AML become resistant to treatment...
View ArticlemiR-137 Suppresses the Phosphorylation of AKT and Improves the Dexamethasone...
Background: Multiple myeloma (MM), a clonal B cell malignancy characterized by the proliferation of plasma cells within the bone marrow, is still an incurable disease, and therefore, finding new...
View ArticleDiscovery of a Novel Anti-Cancer Agent Targeting Both Topoisomerase I & II as...
Cinnamomum verum is used to make the spice cinnamon and has been used for more than 5000 years by both of the two most ancient forms of medicine in the words: Ayurveda and traditional Chinese herbal...
View ArticleEpigenetic Targeting of Platinum Resistant Testicular Cancer
The involvement of epigenetic aberrations in the development and progression of tumors is now well established. However, little is known of the epigenetic alterations in testicular cancer and...
View ArticleEpi-Drugs and Epi-miRs: Moving Beyond Current Cancer Therapies
Epigenetic modifications determine phenotypic characteristics in a reversible, stable and genotype-independent manner. Epigenetic modifications mainly encompass CpG island methylation and histone...
View ArticleE2F1 and NF-κB: Key Mediators of Inflammation-associated Cancers and...
Inflammation is the fundamental protective response; however disordered immuno-response can cause chronic human disease, including cancer. Inflammatory cells and mediators are essential to the tumor...
View ArticleIndoleamine 2,3-dioxygenase (IDO): Biology and Target in Cancer Immunotherapies
Indoleamine 2,3-dioxygenase (IDO) is a heme-containing oxidoreductase that catalyzes the initial and rate-limiting step in the breakdown of non-dietary tryptophan. The biology and immunomodulatory role...
View ArticleMicroRNA as Regulators of Cancer Stem Cells and Chemoresistance in Colorectal...
Colorectal cancer (CRC) is one of the most common cancers worldwide. The development of resistance to anti-cancer treatment is one of the major challenges in the treatment of CRC, which limits the...
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