EGFR High Expression, but not KRAS Status, Predicts Sensitivity of Pancreatic...
Background: Nimotuzumab is shown to be efficacious in advanced pancreatic cancer treatment, but its predictive marker has not been established. Objective: To investigate the impact of EGFR and KRAS...
View ArticleStrong Anti-tumorous Potential of Nardostachys jatamansi Rhizome Extract on...
Background: Glioblastoma has been reckoned as the prime cause of death due to brain tumours, being the most invasive and lethal. Available treatment options, i.e. surgery, radiotherapy, chemotherapy...
View ArticleDoes Hypoxic Response Mediate Primary Resistance to Sunitinib in Untreated...
Background: The antiangiogenic drug sunitinib has never been evaluated as single agent in untreated breast cancer patients. Objective: We aimed to characterize the activity of sunitinib, alone and with...
View ArticleUDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase- 6...
UDP-N-acetyl-D-galactosamine: polypeptide N-acetylgalactosaminyl transferase-6 (pp-GalNAc-T6) is a member of the N-acetyl-D-galactosamine transferase family. It catalyzes the addition of...
View ArticleNovel Synthetic Lethality Approaches for Drug Combinations and Early Drug...
Preclinical evaluation of drug combinations is challenging. In this mini-review we discuss the concept of synthetic lethality and how this can impact on the evaluation of drug combinations and its...
View ArticleOncomicroRNAs-Mediated Tumorigenesis: Implication in Cancer Diagnosis and...
MicroRNAs (miRNAs) control the expression of approximately 60% of protein-coding genes and regulate cell metabolism, proliferation, differentiation, and apoptosis. Notably, aberrant expression of...
View ArticleNovel Strategies to Discover Effective Drug Targets in Metabolic and Immune...
Glioblastoma multiforme is a common primary brain tumor, which exhibits an imbalance between glioma cell growth and glucose metabolism. Recent discoveries have found that the multiple pathways and...
View ArticleLRIGs: A Prognostically Significant Family with Emerging Therapeutic...
The human leucine-rich repeats and immunoglobulin like domains (LRIG) are evolutionary conserved family of single-pass transmembrane proteins. LRIG gene family includes three members, LRIG1 (formerly...
View ArticleCYR61 Confers the Sensitivity to Aromatase Inhibitor Letrozole in ER Positive...
Background: Studies have demonstrated that cysteine-rich 61 (CYR61) may be involved in tumor proliferation and invasion. However, the role of CYR61 plays in endocrine therapy response is largely...
View ArticleGrid-independent Descriptors (GRIND) Analysis and SAR Guided Molecular...
Background: ATP-binding cassette (ABC) transporters, P-glycoprotein (P-gp, ABCB1) and breast cancer resistance protein (BCRP/ABCG2) are major determinants of pharmacokinetic, safety and efficacy...
View ArticlePax5 Re-expression in H460 Cells Treated with the Combination of...
Background: The epigenetic combinations of DNA demethylating agents and histone deacetylase (HDAC) inhibitors have demonstrated clinical benefits for non-small cell lung cancer (NSCLC) treatment,...
View ArticleTargeting Key Metabolic Enzymes Involved in Lipid and Protein Biosyntheses...
The evolution of genomic research enabled the genetic and molecular profiling of breast cancer and revealed the profound complexity and heterogeneity of this disease. Subtypes of breast cancer...
View ArticleRecent Progress in Mutation-driven Therapy, Immunotherapy and Combination...
With increases in our understanding of the human genome and immune system, the treatment armamentarium for melanoma has benefitted from the development and approval of BRAF inhibitors, MEK inhibitors,...
View ArticleCurrent Development of ROS-Modulating Agents as Novel Antitumor Therapy
Compared to normal cells, usually cancer cells are under higher oxidative stress. Elevating intracellular levels of reactive oxygen species (ROS) by introducing excessive ROS or inhibiting antioxidant...
View ArticleUrotensin-II Receptor: A Double Identity Receptor Involved in...
Urotensin II and Urotensin-II receptors are important molecular factors that regulate vasoconstriction and all the diseases that are linked to abnormalities in blood pressure regulation (i.e.:...
View ArticleAnticancer Potential and Molecular Targets of Pristimerin: A Mini- Review
Pristimerin, a natural triterpenoid isolated form Celastrus and Maytenus spp, has been shown to possess a variety of biological and pharmacological effects. Recently, pristimerin has attracted more...
View ArticleThe Role of EGFR-Met Interactions in the Pathogenesis of Glioblastoma and...
Glioblastoma (GBM) is the most common primary malignant brain tumor in adults. It is a devastating and intractable disease with a poor outcome. Aberrant receptor tyrosine kinase signaling is a key...
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