A Rational Approach to Target the Epidermal Growth Factor Receptor in...
Glioblastoma (GBM) is a deadly brain cancer, and all attempts to control it have failed so far. However, the future looks bright, as we now know the molecular landscape of GBM through the work of The...
View ArticleNew Approaches in Glioblastoma Multiforme: The Potential Role of Immune-...
Background: Glioblastoma multiforme (GBM) is the most frequent brain tumor. Despite recent advances in treatment approaches the prognosis remains poor, with a median overall survival of 14.6 months....
View ArticleExploiting Microglial Functions for the Treatment of Glioblastoma
Background: Glioblastoma multiforme (GBM) is the most common brain tumor in adults and is associated with a very low survival rate. The heterogeneity of the tumor microenvironment, its resistance to...
View ArticleMalignant Glioma In Vitro Models: On the Utilization of Stem-like Cells
Recent publications on the molecular characterization of malignant glioma have had profound impact on the appreciation of tumoral heterogeneity within and between patients. Both these phenomena are...
View ArticleHitting a Moving Target: Glioma Stem Cells Demand New Approaches in...
Background: Glioblastoma multiforme (GBM) continues to devastate patients and outfox investigators and clinicians despite the preponderance of research directed at its biology, pathogenesis and...
View ArticleExtracellular Vesicles in Glioblastoma: Role in Biological Processes and in...
Background: Glioblastoma is the most common and malignant form of primary brain cancer; it is characterized by one of the highest mortality among human cancers. Maximal and aggressive surgical...
View ArticleNew Perspectives in Glioblastoma: Nanoparticles-based Approaches
Glioblastoma multiforme represents one of the most aggressive tumor of central nervous system. Current therapy includes surgery, radiation and chemotherapy. These treatments are rarely curative and...
View ArticleInhibition of Aurora A Kinase by Alisertib Induces Autophagy and Cell Cycle...
Background: Aurora A kinase represent a feasible target in cancer therapy. Objective: To evaluate the proteomic response of human liver carcinoma cells to alisertib (ALS) and identify the molecular...
View ArticlePolyphyllin II Restores Sensitization of the Resistance of PC-9/ZD Cells to...
Background: EGFR tyrosine kinase inhibitors (TKIs) are widely used for advanced nonsmall cell lung cancer (NSCLC) patients with a sensitizing EGFR mutation and provide a promising treatment strategy....
View ArticleMechanisms of Tubulin Binding Ligands to Target Cancer Cells: Updates on...
Background: A number of chemically diverse substances bind to the tubulin and inhibit cell proliferation by disrupting microtubule dynamics. There are four binding sites for the ligands binding to the...
View ArticleRole of Genomic Alterations in HER2 Positive Breast Carcinoma: Focus on...
Background: Breast cancer is the most frequently diagnosed life-threatening malignancy among women, across the globe. HER2 positive is a distinct breast cancer subtype, on account of its unique biology...
View ArticleNew Candidate Genes for Lack of Sensitivity to Therapy in Pediatric Leukemias
In the recent years, significant development of molecular genetics has contributed to the better understanding of leukemogenesis and classification of the different leukemia subtypes. Patients...
View ArticleThe Linkage Between Inflammation and Immune Tolerance: Interfering with...
Background: It is widely accepted that chronic inflammation critically contributes to cancer. Immune tolerance in cancer mediates tumor escape from the immune system. The mechanisms of relations...
View ArticleChemotherapy and Cardiotoxicity in Hematologic Malignancies
Introduction: Antineoplastic agents affect the cardiovascular system, and the incidence of cardiotoxicity is continuously growing in patients with hematologic malignancies and treated with...
View ArticleSynthetic Lethal Interactions in Cancer Therapy
Background: Silencing of two or more complementary signaling pathways can lead to cell death, while loss of any single genetic function does not show a severe phnotype, this kind of inter action is...
View ArticleCalcium-calpain Dependent Pathways Regulate Vesiculation in Malignant Breast...
Background: Multidrug resistance in cancer (MDR) occurs when tumours become crossresistant to a range of different anticancer agents. One mechanism by which MDR can be acquired is through cell to cell...
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