Identification of Novel Agents for the Treatment of Brain Metastases of...
Background: Brain cancer from metastasized breast cancer has a high mortality rate in women. The treatment of lesions is hampered in large part by the blood-brain barrier (BBB), which prevents adequate...
View ArticleNSAIDs Induced Regulation of Alternatively Spliced Transcript Isoforms:...
Background: Alternative splicing is one of the post transcriptional modifications through which multiple mRNA isoforms are produced from any gene, also known as splice variants. These are expressed in...
View ArticleHistone Deacetylase Inhibitors for the Treatment of Colorectal Cancer: Recent...
Background: Colorectal cancer is a devastating disease with a dismal prognosis which is heavily hampered by delayed diagnosis. Surgical resection, radiation therapy and chemotherapy are the curative...
View ArticleRecent Advances in Application of Poly-Epsilon-Caprolactone and its...
Background: Due to their excellent biocompatibility and biodegradability, poly-epsiloncaprolactone and its derivative copolymers have been extensively studied as drug carriers in pharmaceutical and...
View ArticleCD20-based Immunotherapy of B-cell Derived Hematologic Malignancies
Background: CD20 is a surface antigen, which is expressed at certain stages of B-cell differentiation. Targeting the CD20-positive B-cells with therapeutic monoclonal antibodies (MAbs) has been an...
View ArticleCathepsin D as a Promising Target for the Discovery of Novel Anticancer Agents
Background: Cathepsin D (CATD), one of the aspartyl endoproteinase involved in different physiological processes and signaling pathways, is accountable for metabolic breakdown of intracellular...
View ArticleIn Vitro Sensitivity Profiling of Neuroblastoma Cells Against A Comprehensive...
Background: Neuroblastoma (NB) constitutes about 8% of all childhood tumors, yet accounts for more than 15% of deaths, with an unacceptable overall survival rate. These rates are despite the current...
View ArticleG9a - An Appealing Antineoplastic Target
Background: G9a is the primary enzyme for mono- and dimethylation at Lys 9 of histone H3 and forms predominantly the heteromeric complex as a G9a-GLP (G9a-like protein) that is a functional histone...
View ArticleEpstein-Barr Virus-associated Gastric Cancer and Potential Mechanisms of...
Introduction: EBV-associated Gastric Cancer (EBVaGC) comprises about 9% of all cases of GC and constitutes a distinct clinicopathological and molecular entity. The pattern of viral expression in EBVaGC...
View ArticleVirus, Oncolytic Virus and Human Prostate Cancer
Background: Prostate cancer (PCa), a disease, is characterized by abnormal cell growth in the prostate - a gland in the male reproductive system. Although older age and a family history of the disease...
View ArticleMolecular Approaches Target to Immunotherapy for HPV-Associated Cancers
Background: Infection with human papillomavirus (HPVs) causes many cancers, which account for about 10-20% of total human cancers. Two recently developed prophylactic vaccines against virus infection...
View ArticleHepatitis B Virus (HBV) Infection and Hepatocellular Carcinoma- New Insights...
Background: Hepatocellular carcinoma (HCC) is the most deadly form of liver cancer. Chronic hepatitis and subsequent liver fibrosis and cirrhosis are the major causes of HCC. HBV infection results not...
View ArticleRole of Oxidative Stress in Hepatitis C Virus Induced Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death worldwide. Hepatitis C virus (HCV) infection is the predominant cause of chronic liver diseases and HCC, particularly in...
View ArticleAnti-Tumorigenic Effects of Resveratrol in Lung Cancer Cells Through...
Background: Resveratrol has been shown to have antioxidant and anti-proliferative properties in multiple cancer types. Here we demonstrate that H460 lung cancer cells are more susceptible to...
View ArticleStudies on Non-synonymous Polymorphisms Altering Human DNA Topoisomerase...
Background: DNA topoisomerase II-α (Top2-α), an essential enzyme for the management of DNA during replication, transcription, recombination, and chromatin remodeling, is one of the most important...
View ArticleThe Role of Mifamurtide in Chemotherapy-induced Osteoporosis of Children with...
Background: Osteosarcoma is the most frequent malignant bone tumor in childhood and young adulthood. Long-term survivors of osteosarcoma patients show high prevalence of osteoporosis and fractures. The...
View ArticleHR+, HER2– Advanced Breast Cancer and CDK4/6 Inhibitors: Mode of Action,...
Background: Cyclin-dependent kinase (CDK) 4/6 inhibitor-based therapies have shown great promise in improving clinical outcomes for patients with hormone receptor-positive (HR+), human epidermal growth...
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