Recent Updates on the Therapeutic Potential of HER2 Tyrosine Kinase...
HER2 positive breast cancer is characterized by the low survival rate in the metastatic patients. Development of resistance and disease-relapse are the major problems associated with the currently...
View ArticlePharmacological Profile and Pharmacogenomics of Anti-Cancer Drugs Used for...
Background: Drugs for targeted therapies are primarily Small Molecules Inhibitors (SMIs), monoclonal antibodies (mAbs), interfering RNA molecules and microRNA. The use of these new agents generates a...
View ArticleThe Real Impact of Target Therapy in Breast Cancer Patients: Between Hope and...
Over the last 15 years, we have seen a huge expansion of the development of drugs directed against biomolecular targets within breast cancer cells. The over-expression of certain receptors (ER, PgR,...
View ArticleCurrent and Emerging Treatments for Metastatic Renal Cell Carcinoma
In the last decades, the treatment of mRCC, metastatic Renal Cell Carcinoma, has become more and more complex due to the approval of a great number of effective systemic treatments that have...
View ArticleOptimal Management of Prostate Cancer Based on its Natural Clinical History
Prostate cancer is the most common malignancy in males and, despite a marked improvement in diagnostic techniques, a not small percentage of prostate tumours is still diagnosed in advanced stage. It is...
View ArticleMelanoma Adjuvant Treatment: Current Insight and Clinical Features
Melanoma represents 2-3% of all cancers, 95% of them arise from skin, while only 5% are non-cutaneous melanoma. Despite an optimal surgery management, the risk of a local and systemic relapse remains...
View ArticleThe Role of Target Therapy in the Treatment of Gastrointestinal Noncolorectal...
Gastrointestinal (GI) tumors are among the leading cause of death in cancer patients worldwide. Particularly, gastric cancer (GC) is the third cause of cancer deaths, whereas esophageal neoplasm is the...
View ArticleMetastatic Colorectal Cancer: Role of Target Therapies and Future Perspectives
Today, we are experiencing a real cultural revolution in the therapeutic approach to cancer of the colon - rectum, that by orphan disease, it is now becoming an important paradigm of scientific...
View ArticleCancer Targeted Therapy Strategy: The Pathologist’s Perspectives
The effectiveness of new personalized treatment procedures in oncology is based on the fact that certain tumors exhibit specific molecular features. More in detail, neoplastic tissues of patients...
View ArticleClinical Effectiveness and Cost-effectiveness of Target Therapies for Adult...
Treatment for advanced non-small cell lung cancer has changed in the last two decades, with many new drugs, mostly target agents, included in the algorithm, improvement of progression free survival and...
View ArticleCX-4945, a Selective Inhibitor of Casein Kinase 2, Synergizes with B Cell...
Background: Approximately one third of Diffuse Large B cell Lymphomas (DLBCL) are refractory or relapse. Novel therapeutic approaches under scrutiny include inhibitors of B-cell receptor (BCR)...
View ArticleRedox Biotransformation and Delivery of Anthracycline Anticancer Antibiotics:...
Background: Quantum chemical methods and molecular mechanics approaches face a lot of challenges in drug metabolism study because of either insufficient accuracy, huge computational cost, or lack of...
View ArticleDiallyl Disulfide Inhibits Breast Cancer Stem Cell Progression and Glucose...
Background: It has been reported that diallyl disulfide (DADS) has anti-proliferative activity in many cancers. Objective: The purpose of this study was to investigate the functions of DADS and the...
View ArticleOncolytic Tanapoxvirus Expressing Interleukin-2 is Capable of Inducing the...
Background: Oncolytic viruses (OVs), which preferentially infect cancer cells and induce host anti-tumor immune responses, have emerged as an effective melanoma therapy. Tanapoxvirus (TANV), which...
View ArticleFertility Drugs and Ovarian Cancer
The aetiology of ovarian cancer is multifactorial with both endogenous and exogenous risk factors playing an important role. The exact pathogenesis of ovarian cancer is still not well understood,...
View ArticleRole of Glioma-associated GLI1 Oncogene in Carcinogenesis and Cancertargeted...
Glioma-associated oncogenes (GLIs) are zinc finger protein family members and downstream regulatory factors of the classic Hedgehog (Hh) signaling pathway. GLI proteins influence the growth and...
View ArticleOxidative Stress and Cancer: The Role of Nrf2
Oxidative stress due to imbalance between ROS production and detoxification plays a pivotal role in determining cell fate. In response to the excessive ROS, apoptotic signaling pathway is activated to...
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