Towards Prevention of Ovarian Cancer
Ovarian cancer is the leading cause of death of all gynaecological cancers. To date, there is no reliable, specific screening procedure for detecting ovarian cancer. The risk factors of ovarian cancer...
View ArticleTunneling Nanotubes: A Versatile Target for Cancer Therapy
Currently Cancer is the leading cause of death worldwide. Malignancy or cancer is a class of diseases characterized by uncontrolled cell growth that eventually invade other tissues and develop...
View ArticleEvaluation of Anti-cancer Activity of Stilbene and Methoxydibenzo[b,f] oxepin...
Background: Stilbenes, 1,2-diphenylethen derivatives, including resveratrol and combretastatins, show anticancer features especially against tumor angiogenesis. Fosbretabulin, CA-4, in combination with...
View ArticleMetastatic Site Location Influences the Diagnostic Accuracy of ctDNA EGFR-...
Background: Recent studies evaluated the diagnostic accuracy of circulating tumor DNA (ctDNA) analysis in the detection of epidermal growth factor receptor (EGFR) mutations from plasma of NSCLC...
View ArticleAn Update on Circumventing Multidrug Resistance in Cancer by Targeting...
Background: The ultimate emergence of multidrug resistance remains a severe limitation of chemotherapy treatment for patients with cancer. The best-characterized cause of drug resistance involves the...
View ArticleClinical Evidence on the Magnitude of Change in Growth Pathway Activity in...
Background: Despite prolonged disease-free survival and overall survival rates in Estrogen Receptor (ER)-positive patients undergoing adjuvant treatment, Tamoxifen therapy tends to fail due to eventual...
View ArticleDegradation of Androgen Receptor through Small Molecules for Prostate Cancer
Prostate cancer is the most common carcinoma among aged males in western countries and more aggressive and lethal castration resistant prostate cancer often occurs after androgen deprivation therapy....
View ArticleRegulation of MicroRNAs by Phytochemicals: A Promising Strategy for Cancer...
A growing body of evidence suggests that phytochemicals are potentially able to affect a variety of cellular processes, including proliferation, apoptosis, cell-cycle control, angiogenesis,...
View ArticleAutophagy as a Potential Therapeutic Target in Breast Cancer Treatment
One of the crucial reasons of breast cancer therapy failure is an impairment of mechanisms responsible for metabolism and cellular homeostasis, which makes it difficult to foresee the response to the...
View ArticleRole of miR-193a in Cancer: Complexity and Factors Control the Pattern of its...
Background: There is emerging data suggesting that the non-coding RNA (microRNA 193a or miR-193a) plays key roles in different types of cancers. Objective: This review aims to investigate the...
View ArticleJQ1, a BET Inhibitor, Synergizes with Cisplatin and Induces Apoptosis in...
Background: Malignant Pleural Mesothelioma (MPM) is an asbestos-associated tumor with poor prognosis and few therapeutic options. JQ1, a selective antagonist of BRD4, modulates transcription of...
View ArticleA High-throughput Quantitative Expression Analysis of Cancer-related Genes in...
Background: Citrus bioactive compounds, as active anticancer agents, have been under focus by several studies worldwide. However, the underlying genes responsible for the anticancer potential have not...
View ArticleDevelopment of Drug Targeting and Delivery in Cervical Cancer
Cervical cancer is the second most common cancer in women. Standard treatment options available for cervical cancer include chemotherapy, surgery and radiation therapy associated with their own side...
View ArticleTherapeutic Approaches for the Treatment of Epidermal Growth Factor Receptor...
Lung cancer surfaces to be the predominant determinant of mortality worldwide constituting 13% and 19% of all new cancer cases and deaths related to cancer respectively. Molecular profiling has now...
View Articlep53-Mdm2 Interaction Inhibitors as Novel Nongenotoxic Anticancer Agents
Background: Cancer is a major global health problem with high mortality rate. Most of the clinically used anticancer agents induce apoptosis through genotoxic stress at various stages of cell cycle and...
View ArticleSignificant Role of MUC1 in Development of Resistance to Currently Existing...
As an extensively glycosylated transmembrane protein of epithelium, Mucin1 (MUC1) mostly protects cells from tensions induced by external milieu. Physiologically, during stress condition, MUC1...
View ArticleThe Safety, Efficacy and Therapeutic Potential of Histone Deacetylase...
Histone deacetylase inhibitors (HDACi) have been demonstrated as an emerging class of anticancer drugs involved in regulation of gene expression and chromatin remodeling thus indicating valid targets...
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