Aldose Reductase Inhibitor, Fidarestat Prevents High-fat Diet-induced...
Background: Recent epidemiological and experimental studies have shown that obesity is a major risk factor for Colorectal Cancer (CRC). Regular intake of high fat-containing diet can promote obesity...
View ArticleSOCS6 Functions as a Tumor Suppressor by Inducing Apoptosis and Inhibiting...
Background: Our previous studies revealed that the downregulation of Suppressor of cytokine signaling 6 (SOCS6) was correlated with malignant progression of human prostate cancer (PCa). Aims: In the...
View ArticleParp Inhibitors for the Treatment of Ovarian Cancer
The standard of treatment for advanced ovarian cancer is represented by optimal surgical debulking preceded or followed by chemotherapeutic regimens including taxanes and platinum agents, possibly...
View ArticleAR Copy Number and AR Signaling-directed Therapies in Castrationresistant...
Background: Adaptive upregulation of Androgen Receptor (AR) is the most common event involved in the progression from hormone sensitive to Castration-Resistant Prostate Cancer (CRPC). AR signaling...
View ArticleAntibody Based EpCAM Targeted Therapy of Cancer, Review and Update
Todays, after four decades from the discovery of monoclonal antibodies by Kohler and Milstein in 1975, a dozen of antibodies are used in cancer targeted therapy with different strategies. The success...
View ArticlePonatinib: A Review of Efficacy and Safety
Ponatinib is a third generation kinase inhibitor designed to overcome the gatekeeper T315I mutation. In different trials this drug showed inhibitory activity against native BCR-ABL1 kinase and several...
View ArticlePharmacoinformatic Approaches to Design Novel Inhibitors of Protein Kinase B...
Background: Protein kinase B (PKB/Akt) belongs to the AGC superfamily of related serine/ threonine kinases with three structurally homologous mammalian isoforms, Akt1 (PKBα), Akt2 (PKBβ), and Akt3...
View ArticleThe Anti-malarial Drug Artesunate Blocks Wnt/β-catenin Pat hway and...
Background: Uveal melanoma is the most common primary intraocular malignancy in adults. So far, there have been no effective targeted therapeutic agents in patients with uveal melanoma. Artesunate is a...
View ArticleTargeting FGFR with BGJ398 in Breast Cancer: Effect on Tumor Growth and...
Background: Endocrine resistance and metastatic dissemination comprise major clinical challenges for breast cancer treatment. The fibroblast growth factor receptor family (FGFR) consists of four...
View ArticleMolecular Mechanisms of Resistance in Testicular Germ Cell Tumors - clinical...
Testicular germ cell tumors (TGCTs) represent the most common malignancy in men aged 15-35. Due to these tumors’ biological and clinical characteristics, they can serve as an appropriate system for...
View ArticleAnticancer Properties of Essential Oils: An Overview
Background: Essential oils are complex mixtures of low molecular weight compounds extracted from plants. Their main constituents are terpenes and phenylpropanoids, which are responsible for their...
View ArticlePRDM14: A Potential Target for Cancer Therapy
PRDM14 belongs to the PR domain-containing (PRDM) family. Although a precise understanding focused on the function of PRDM14 to maintain stemness and pluripotency in embryonic stem cells via epigenetic...
View ArticleRole of MicroRNAs in Treatment Response in Prostate Cancer
Prostate cancer (PCa) is the most common non-skin cancer in men worldwide, resulting in significant mortality and morbidity. Depending on the grade and stage of the cancer, patients may be given...
View ArticleNoxa: Role in Cancer Pathogenesis and Treatment
The B-cell lymphoma 2 (Bcl-2) family proteins play an important role in regulating apoptosis, or programmed cell death, in response to several extracellular and intracellular signals. These proteins...
View ArticleThe Anti-malarial Drug Artesunate Blocks Wnt/β-catenin Pathway and...
Background: Uveal melanoma is the most common primary intraocular malignancy in adults. So far, there have been no effective targeted therapeutic agents in patients with uveal melanoma. Artesunate is a...
View ArticleLinc01638 Promotes Tumorigenesis in HER2+ Breast Cancer
Background: Long non-coding RNAs play crucial roles in various biological activities and diseases. The role of long intergenic non-coding RNA01638 (linc01638) in breast cancer, especially in...
View ArticleSpecific Targeting of HER2-Positive Head and Neck Squamous Cell Carcinoma...
Background: Expression of human epidermal growth factor receptor type 2 (HER2) in head and neck squamous cell carcinoma (HNSCC) cell line HN5 can be employed with great opportunities of success for...
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