The Association of Neuronal Stress with Activating Transcription Factor 3 in...
Background: The notion that proteasome inhibitor bortezomib (BTZ) induced intracellular oxidative stress resulting in peripheral neuropathy has been generally accepted. The association of mitochondrial...
View ArticleCrizotinib Versus Chemotherapy on ALK-positive NSCLC: A Systematic Review of...
Introduction: Crizotinib was approved to treat anaplastic lymphoma kinase (ALK)- positive non-small cell lung cancer (NSCLC) by the Food and Drug Administration in 2011.We conducted a systematic review...
View ArticleGlycolysis Inhibition as a Strategy for Hepatocellular Carcinoma Treatment?
Hepatocellular carcinoma (HCC) is the most frequently detected primary malignant liver tumor, representing a worldwide public health problem due to its high morbidity and mortality rates. The HCC is...
View ArticleInterrupting the FGF19-FGFR4 Axis to Therapeutically Disrupt Cancer Progression
Coordination between the amplification of the fibroblast growth factor FGF19, overexpression of its corresponding receptor FGFR4, and hyperactivation of the downstream transmembrane enzyme β-klotho has...
View ArticleCutaneous Application of Celecoxib for Inflammatory and Cancer Diseases
Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) and particularly selective cyclooxygenase-2 (COX-2) inhibitors such as celecoxib (Cxb) are considered promising cancer chemopreventive for...
View ArticleCathepsin L Induces Proangiogenic Changes in Human Omental Microvascular...
Background: Metastasis still remains the major cause of therapeutic failure, poor prognosis and high mortality in epithelial ovarian cancer (EOC) patients. Previously, we showed that EOC cells secrete...
View ArticleThe Biological Activity of the Novel Vinca Alkaloids 4-chlorochablastine and...
Background: Vinca alkaloids are important cancer drugs belonging to the class of antimitotic agents. The most commonly used substances are vinblastine and vincristine, other compounds are vinorelbine...
View ArticleTumor-dependent Effects of Proteoglycans and Various Glycosaminoglycan...
Background: The small leucine-rich proteoglycans (SLRPs) biglycan (BGN) and decorin (DCN) linked with sulfated glycosaminoglycan (GAG) chains exhibit oncogenic or tumor suppressive potentials depending...
View ArticleEfficacy and Safety of Antigen-specific Immunotherapy in the Treatment of...
Background and Objective: We performed this systematic review and meta-analysis to assess the efficacy and safety of antigen-specific immunotherapy (Belagenpumatucel-L, MAGE-A3, L-BLP25, and TG4010) in...
View ArticleMacrophage Flipping from Foe to Friend: A Matter of Interest in Breast...
Tumor heterogeneity within various cancer types including breast carcinoma is pivotal in the manifestations of tumor hallmarks. Tumor heterogeneity is seen as a common landscape where intra-tumoral...
View ArticleFocal Adhesion Kinase in Ovarian Cancer: A Potential Therapeutic Target for...
Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase, which is an essential player in regulating cell migration, invasion, adhesion, proliferation, and survival. Its overexpression and...
View ArticleInhaled Micro/Nanoparticulate Anticancer Drug Formulations: An Emerging...
Local delivery of drug to the target organ via inhalation offers enormous benefits in the management of many diseases. Lung cancer is the most common of all cancers and it is the leading cause of death...
View ArticleFormulation, Pharmacokinetic Evaluation and Cytotoxicity of an Enhanced-...
Background: Improving poorly soluble drugs into druggability was a major problem faced by pharmaceutists. Nanosuspension can improve the druggability of insoluble drugs by improving the solubility,...
View ArticleGene Therapy and Photothermal Therapy of Layer-by-Layer Assembled AuNCs...
Background: MicroRNA (miRNA) therapy, which was widely considered to treat a series of cancer, has been confronted with numerous obstacles to being delivered into target cells because of its easy...
View ArticleIn Vitro and In Vivo Antimetastatic Effects of ZSTK474 on Prostate Cancer...
Background: The lethality of prostate cancer is mainly due to metastasis. Inhibition of metastasis is expected to be a promising approach for prostate cancer therapy. Phosphatidylinositol 3-kinase...
View ArticleConjugation of Phthalocyanine Photosensitizer with Poly(amidoamine)...
Objective: To improve solubility and to reduce aggregation, ZnPcC4 was conjugated to a third-generation poly-amidoamine dendrimer with amino end group (G3-PAMAM-NH2), which acts as a novel photodynamic...
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