Oral Drug Delivery Systems for Ulcerative Colitis Therapy: A Comparative...
Background: Oral administrations of microparticles (MPs) and nanoparticles (NPs) have been widely employed as therapeutic approaches for the treatment of ulcerative colitis (UC). However, no previous...
View ArticleHAMPT, A Novel Quadruple Drug Combination Designed for Cancer Metastatic...
Background: Highly Active Metastasis Preventing Therapy (HAMPT) is a quardruple drug combination consisting of mifepristone, aspirin, lysine and doxycycline. Objective: Based on our previous study,...
View ArticleMesoporous Silica Nanoparticles as a Prospective and Promising Approach for...
Background: With the development of nanotechnology, nanocarrier has widely been applied in such fields as drug delivery, diagnostic and medical imaging and engineering in recent years. Among all of the...
View ArticleThe Evaluation of Animal Models in the Development of Anticancer Agents: From...
Background: One of the main reasons for most of the anticancer drugs to fail in the late preclinical testing and early clinical trials is the differences in drug effects observed from animals and...
View ArticleChallenges and Opportunities from Basic Cancer Biology for Nanomedicine for...
Background: Effective cancer therapy is still a great challenge for modern medical research due to the complex underlying mechanisms of tumorigenesis and tumor metastasis, and the limitations commonly...
View ArticleUrsolic Acid in Cancer Treatment and Metastatic Chemoprevention: From...
Background: Cancer metastasis has emerged as a major public health threat that causes majority of cancer fatalities. Traditional chemotherapeutics have been effective in the past but suffer from low...
View ArticleBlocking IL-6/GP130 Signaling Inhibits Cell Viability/Proliferation,...
Background: Elevated production of the pro-inflammatory cytokine interleukin-6 (IL-6) and dysfunction of IL-6 signaling promotes tumorigenesis and are associated with poor survival outcomes in multiple...
View ArticleIn Silico Structure Modeling and Molecular Docking Analysis of Phosphoribosyl...
Background: Cancer remains one of the most serious disease worldwide. Robust metabolism is the hallmark of cancer. PPAT (phosphoribosyl pyrophosphate amidotransferase) catalyzes the first committed...
View ArticleToxicology of Trastuzumab: An Insight into Mechanisms of Cardiotoxicity
Trastuzumab is a humanized monoclonal antibody that is approved for the treatment of breast and gastric malignancies. Although it has shown promise as a biotherapeutic, its cardiotoxicity remains a...
View ArticleThe RNA Binding Protein HuR: a Promising Drug Target for Anticancer Therapy
The stability of mRNA is one of the key factors governing the regulation of eukaryotic gene expression and function. Human antigen R (HuR) is an RNA-binding protein that regulates the stability,...
View ArticleCombination Therapies Using Metformin and/or Valproic Acid in Prostate...
Prostate cancer (PCa) is the most frequent cancer in men. The evolution from local PCa to castration-resistant PCa, an end-stage of disease, is often associated with changes in genes such as p53,...
View ArticlePolyploid Giant Cancer Cells (PGCCs): The Evil Roots of Cancer
Polyploidy is associated with increased cell size and is commonly found in a subset of adult organs and blastomere stage of the human embryo. The polyploidy is formed through endoreplication or cell...
View ArticleTargeting Glycosylation Aberrations to Improve the Efficiency of Cancer...
The use of photodynamic therapy in cancer still remains limited, partly because of the lack of photosensitizer (PS) specificity for the cancerous tissues. Various molecular tools are available to...
View ArticleCharacterization of YY1 OPB Peptide for its Anticancer Activity
Background: The oncoprotein binding (OPB) domain of Yin Yang 1 (YY1) consists of 26 amino acids between G201 and S226, and is involved in YY1 interaction with multiple oncogene products, including...
View ArticleInhibition of the ATPase Domain of Human Topoisomerase IIa on HepG2 Cells by...
Background: The major attention has been received by the natural products in the prevention of diseases due to their pharmacological role. Objective: The major focus of the study was to search for...
View Articlec-Myc Inhibitor 10074-G5 Induces Murine and Human Hematopoietic Stem and...
Background: c-Myc plays a major role in the maintenance of glycolytic metabolism and hematopoietic stem cell (HSC) quiescence. Objective: Targeting modulators of HSC quiescence and metabolism could...
View ArticleThe Multifunctional Protein p62 and Its Mechanistic Roles in Cancers
The multifunctional signaling hub p62 is well recognized as a ubiquitin sensor and a selective autophagy receptor. As a ubiquitin sensor, p62 promotes NFκB activation by facilitating TRAF6...
View ArticleTargeting Membrane Receptors of Ovarian Cancer Cells for Therapy
Ovarian cancer is a leading cause of death worldwide from gynecological malignancies, mainly because there are few early symptoms and the disease is generally diagnosed at an advanced stage. In...
View ArticleExploring Proteomic Drug Targets, Therapeutic Strategies and Protein -...
Protein-Protein Interactions (PPIs) drive major signalling cascades and play critical role in cell proliferation, apoptosis, angiogenesis and trafficking. Deregulated PPIs are implicated in multiple...
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