EH-42: A Novel Small Molecule Induces Apoptosis and Inhibits Migration and...
Background: Since signal transducer and activator of transcription 3 (STAT3) is aberrantly activated in hepatocellular carcinoma (HCC) and plays a key role in this tumor progression. Inhibition of the...
View ArticleTargeting Upstream Kinases of STAT3 in Human Medulloblastoma Cells
Background: Medulloblastoma is the most common malignant brain tumor in children. Despite improvement in overall survival rate, it still lacks an effective targeted treatment strategy. The Janus family...
View ArticleInteractions of Vascular Endothelial Growth Factor and p53 with miR-195 in...
Background: The clinical pathological features, as well as the cellular mechanisms of miR-195, have not been investigated in thyroid carcinoma. Objective: The aim of this study is to identify the...
View ArticleXiao-Chai-Hu-Tang (XCHT) Intervening Irinotecan’s Disposition: The Potential...
Background: Diarrhea is a severe side effect of irinotecan, a pro-drug of SN-38 used for the treatment of many types of cancers. Pre-clinical and clinical studies showed that decreasing the colonic...
View ArticleTargeting Strategies for Glucose Metabolic Pathways and T Cells in Colorectal...
Colorectal cancer is a heterogeneous group of diseases that result from the accumulation of different sets of genomic alterations, together with epigenomic alterations, and it is influenced by...
View ArticleNanotherapy Targeting the Tumor Microenvironment
Cancer is characterized by high mortality and low curability. Recent studies have shown that the mechanism of tumor resistance involves not only endogenous changes to tumor cells, but also to the tumor...
View ArticleHSF1 as a Cancer Biomarker and Therapeutic Target
Heat shock factor 1 (HSF1) was discovered in 1984 as the master regulator of the heat shock response. In this classical role, HSF1 is activated following cellular stresses such as heat shock that...
View ArticleOverexpression of Nemo-like Kinase Promotes the Proliferation and Invasion of...
Background: Nemo-like kinase (NLK) is an evolutionarily conserved MAP kinaserelated kinase involved in the pathogenesis of several human cancers. Objective: The aim of this study was to investigate the...
View ArticleOsimertinib Quantitative and Gene Variation Analyses in Cerebrospinal Fluid...
Background: Leptomeningeal metastases (LM) are much more frequent in patients of non-small lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR) mutations. Osimertinib, a...
View ArticleCT-707 Overcomes Resistance of Crizotinib through Activating PDPK1- AKT1...
Background: Crizotinib established the position of anaplastic lymphoma kinase-tyrosine kinase inhibitors (ALK-TKI) in the treatment of non-small cell lung cancer (NSCLC) while the therapy- resistance...
View ArticleGender Differences in the Antioxidant Response to Oxidative Stress in...
Background: Brain tumorigenesis is related to oxidative stress and a decreased response of antioxidant defense systems. As it is well known that gender differences exist in the incidence and survival...
View ArticleBone Invasive Properties of Oral Squamous Cell Carcinoma and its Interactions...
Background: Co-culture of cancer cells with alveolar bone cells could modulate bone invasion and destructions. However, the mechanisms of interaction between oral squamous cell carcinoma (OSCC) and...
View ArticleMolecular Mechanisms and Targeted Therapies Including Immunotherapy for...
Lung cancer is the leading cause of cancer death worldwide. Molecular targeted therapy has greatly advanced the field of treatment for non-small cell lung cancer (NSCLC), which accounts for the...
View ArticleDifferential Expression of TOM34, AL1A1, PADI2 and KLRBA in NNK Induced Lung...
Background: Lung cancer is the most common cancer with a high mortality rate. The diagnosis only at advanced stages and lack of effective treatment are the main factors responsible for high mortality....
View ArticleAdvances in In-Silico based Predictive In-Vivo Profiling of Novel Potent...
Background: Intestinal β-glucuronidase enzyme has a significant importance in colorectal carcinogenesis. Specific inhibition of the enzyme helps prevent immune reactivation of the glucuronide-...
View ArticleStudy of Serum Soluble Programmed Death Ligand 1 as a Prognostic Factor in...
Background: The expression of programmed cell death ligands on tumor cells has a role in the suppression of antitumor immunity, resulting in tumor immune evasion. Objective: In this study, we evaluated...
View ArticleMogroside V Inhibits Hyperglycemia-induced Lung Cancer Cells Metastasis...
Background: Diabetes Mellitus (DM) accelerates progress of lung cancer. Hyperglycemia, a critical feature of DM, promotes lung cancer metastasis. Mogroside V is a triterpenoid glycoside from Siraitia...
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