Cancer Stem Cells Equipped with Powerful Hedgehog Signaling and Better...
Complex nature of the tumor is depicted at the cellular landscape by showing heterogeneity in the presence of cancer cells, cancer-associated stromal cells, mesenchymal stem cells and cancer stem cells...
View ArticleThe Role of Large Neutral Amino Acid Transporter (LAT1) in Cancer
Background: The solute carrier family 7 (SLC7) can be categorically divided into two subfamilies, the L-type amino acid transporters (LATs) including SLC7A5-13, and SLC7A15, and the cationic amino acid...
View ArticleThe Role of Shcbp1 in Signaling and Disease
Src homolog and collagen homolog (Shc) proteins have been identified as adapter proteins associated with cell surface receptors and have been shown to play important roles in signaling and disease....
View ArticleC/EBPα Regulates FOXC1 to Modulate Tumor Growth by Interacting with...
Background: Forkhead box C1 (FOXC1) is an important cancer-associated gene in tumor. PPAR-γ and C/EBPα are both transcriptional regulators involved in tumor development. Objective: We aimed to clarify...
View ArticleSam68 Promotes the Progression of Human Breast Cancer through inducing...
Background: Src associated with mitosis of 68 kDa (Sam68), is often highly expressed in human cancers. Overexpression of Sam68 has been shown to be correlated with poor survival prognosis in some...
View ArticleERGIC3 Silencing Additively Enhances the Growth Inhibition of BFA on Lung...
Background: Brefeldin A (BFA) has been known to induce endoplasmic reticulum stress (ERS) and Golgi body stress in cancer cells. ERGIC3 (endoplasmic reticulum-Golgi intermediate compartment 3) is a...
View ArticleWell-defined Graphene Oxide as a Potential Component in Lung Cancer Therapy
Background: Graphene oxide (GO) has unique physical and chemical properties that can be used in anticancer therapy - especially as a drug carrier. Graphene oxide, due to the presence of several hybrid...
View ArticleEllipticine, its Derivatives: Re-evaluation of Clinical Suitability with the...
Targeted drug delivery systems gave newer dimensions for safer and more effective use of therapeutic drugs, thus helping in circumventing the issues of toxicity and unintended drug accumulation. These...
View ArticleNatural DNA Intercalators as Promising Therapeutics for Cancer and Infectious...
Cancer and infectious diseases are one of the greatest challenges of modern medicine. An unhealthy lifestyle, the improper use of drugs, or their abuse are conducive to the increase of morbidity and...
View ArticleAnti-VEGF/VEGFR2 Monoclonal Antibodies and their Combinations with PD-1/PD-L1...
The vascular endothelial growth factor (VEGF)/VEGF receptor 2 (VEGFR2) signaling pathway is one of the most important pathways responsible for tumor angiogenesis. Currently, two monoclonal antibodies,...
View ArticleCDK12 Promotes Breast Cancer Progression and Maintains Stemness by Activating...
Background: CDK12 is a promising therapeutic target in breast cancer with an effective ability of maintaining cancer cell stemness. Objective: We aim to investigate the mechanism of CDK12 in...
View ArticleUptake of [¹⁸F]tetrafluoroborate in MCF-7 Breast Cancer Cells is Induced...
Background: The human sodium iodide symporter (hNIS) has been the most important target in nuclear medicine regarding thyroid-related diseases. Although hNIS-expression can also be determined in...
View ArticleResveratrol as an Adjuvant for Normal Tissues Protection and Tumor Sensitization
Cancer is one of the most complicated diseases in present-day medical science. Yearly, several studies suggest various strategies for preventing carcinogenesis. Furthermore, experiments for the...
View ArticleNovel Mechanistic Insights into the Anti-cancer Mode of Arsenic Trioxide
Arsenic, a naturally-occurring toxic element, and a traditionally-used drug, has received a great deal of attention worldwide due to its curative anti-cancer properties in patients with acute...
View ArticleAnti-tumor Activity of Propofol: A Focus on MicroRNAs
Background: MicroRNAs are endogenous, short, non-coding RNAs with the length as low as 20 to 25 nucleotides. These RNAs are able to negatively affect the gene expression at the post-transcriptional...
View ArticleNordihydroguaiaretic Acid in Therapeutics: Beneficial to Toxicity Profiles...
Nordihydroguaiaretic acid (NDGA) is a plant lignan obtained from creosote bush, Larrea tridentata and is known to possess antioxidant, anticancer activities and is used in traditional medicine in North...
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