Use of Small-molecule Inhibitory Compound of PERK-dependent Signaling Pathway...
Background: Colorectal cancer constitutes one of the most common cancer with a high mortality rate. The newest data has reported that activation of the pro-apoptotic PERK-dependent unfolded protein...
View ArticleEffects of Intermittent Hypoxia on Expression of Glucose Metabolism Genes in...
Background: Hypoxic condition induces molecular alterations which affect the survival rate and chemo-resistant phenotype of cancer cells. Objective: The aim of this study is to investigate the...
View ArticlePPARγ Agonists in Combination Cancer Therapies
Peroxisome proliferator-activated receptor-gamma (PPARγ) is a nuclear receptor acting as a transcription factor involved in the regulation of energy metabolism, cell cycle, cell differentiation, and...
View ArticleThe Potential Use of Anticancer Peptides (ACPs) in the Treatment of...
Peptides have acquired increasing interest as promising therapeutics, particularly as anticancer alternatives during recent years. They have been reported to demonstrate incredible anticancer...
View ArticleCancer Cell-derived Secretory Factors in Breast Cancer-associated Lung...
In Breast cancer, Lung is the second most common site of metastasis after the bone. Various factors are responsible for Lung metastasis occurring secondary to Breast cancer. Cancer cellderived...
View ArticleDisintegrin Tablysin-15 Suppresses Cancer Hallmarks in Melanoma Cells by...
Background: Integrins are crucial anti-cancer therapy targets. We previously showed that tablysin-15 is an integrin antagonist with its Arg-Gly-Asp motif in a novel structural context. Objective: Here...
View ArticleIn Vitro Investigation Demonstrates IGFR/VEGFR Receptor Cross Talk and...
Background: Atypical teratoid rhabdoid tumor of the central nervous system (CNS ATRT) is a malignancy that commonly affects young children. The biological mechanisms contributing to tumor...
View ArticlecircEPSTI1 Acts as a ceRNA to Regulate the Progression of Osteosarcoma
Background: Recent studies have reported the vital roles of circular RNAs (circRNAs) in tumor progression. However, the function and expression profile of most circRNAs in osteosarcoma remain unclear....
View ArticleLipid-based Nanoplatforms in Cancer Therapy: Recent Advances and Applications
Though modern available cancer therapies are effective, they possess major adverse effects, causing non-compliance to patients. Furthermore, the majority of the polymeric-based medication platforms are...
View ArticleOld and New Approaches to Target the Hsp90 Chaperone
The 90-kDa heat shock protein (Hsp90) is a molecular chaperone that ensures cellular proteostasis by maintaining the folding, stabilization, activation, and degradation of over 400 client proteins....
View ArticleTargeting Proliferating Cell Nuclear Antigen (PCNA) as an Effective Strategy...
Targeting highly proliferating cells is an important issue for many types of aggressive tumors. Proliferating Cell Nuclear Antigen (PCNA) is an essential protein that participates in a variety of...
View ArticleStudy of Toll-like Receptor 3 Gene Polymorphism as a Novel Risk Factor for...
Background and Aims: Hepatocellular carcinoma (HCC) is a highly aggressive cancer with few treatment options. Toll-like receptor 3 (TLR3) plays a key role in innate immunity and may affect the...
View ArticleFas Ligand Enhances Apoptosis of Human Lung Cancer Cells Cotreated with...
Background: Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) play key roles in the antiviral response, but recent works show that RLR activation elicits anticancer activity as well,...
View ArticleThe Potential Targets and Mechanisms of a Carbazole and Pyrazole Containing...
Aims: Characterization of a small anticancer compound. Background: The development of small molecules as new anti-cancer therapeutics is necessary to improve anti-tumor efficacy and reduce toxicities,...
View ArticleHypermethylation of Single CpG Dinucleotides at the Promoter of CXCL13 Gene...
Background: Chemokine 13 (CXCL13) and its chemokine receptor 5 (CXCR5) are involved in the onset of various types of cancer. However, their role in cervical cancer (CC) remains unknown. Objective: To...
View ArticleIdronoxil as an Anticancer Agent: Activity and Mechanisms
Idronoxil has been the subject of more than 50 peer-reviewed publications over the last two decades. This isoflavone is an intriguing regulator of multiple signal transduction pathways, capable of...
View ArticleNovel Homeodomain Transcription Factor Nkx2.2 in the Brain Tumor Development
Background: Complex central nervous system (CNS) is made up of neuronal cells and glial cells. Cells of central nervous system are able to regenerate after injury and during repairing. Sonic hedgehog...
View ArticleA Review of IGF1 Signaling and IGF1-related Long Noncoding RNAs in...
Cancer is still a serious public issue that humans face. Chemoresistance is one of the most important reasons for relapse and poor prognosis. The accumulated data support that the polymorphisms in IGF1...
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