CDK9: Therapeutic Perspective in HCC Therapy
CDK9 is an important cell-cycle control enzyme essential in transcription, elongation, and mRNA maturation. Overexpression of CDK9 has been reported in several diseases, including acute lymphoblastic...
View ArticleCircRNA SCARB1 Promotes Renal Cell Carcinoma Progression Via Mir- 510-5p/SDC3...
Background: Emerging studies have indicated that circular RNAs (circRNAs) play important roles in the development of many tumors. CircRNA-scavenger receptor class B member 1 (Circ-SCARB1) was...
View ArticleImmune Checkpoint Regulators: A New Era Toward Promising Cancer Therapy
During the last century, our battle against cancer has been inaugurated upon three main approaches; surgery, radiation and chemotherapy. The latest findings on the effectiveness of immunotherapy in...
View ArticleThe Therapeutic Potential of MEK1/2 Inhibitors in the Treatment of...
The mitogen-activated protein kinase (MAPK) pathway is among the key factors in numerous cellular processes involved in tumorigenesis, suggesting it as a potential therapeutic target in gynecological...
View ArticleCOVID-19 Pandemic: Experiences in China and Implications for its Prevention...
The outbreak of COVID-19 due to SARS-CoV-2 originally emerged in Wuhan in December 2019. As of March 22, 2020, the disease spread to 186 countries, with at least 305,275 confirmed cases. Although there...
View ArticleUpdated Review and Perspective on 20S Proteasome Inhibitors in the Treatment...
Lung cancer is the leading cause of cancer-related deaths worldwide. Most lung cancer patients are diagnosed at advanced stages and may benefit from pembrolizumab (anti-PD-1 antibody), cytotoxic...
View ArticleHepatitis C Virus Infection and Treatment as Independent Prognostic Factors...
Background: Egypt is one of the highest hepatitis C virus (HCV) endemic areas. Chronic HCV infection has extra-hepatic manifestations, including non-Hodgkin lymphoma (NHL). Diffuse large B-cell...
View ArticleOverexpression of p62 Induces Autophagy and Promotes Proliferation, Migration...
Background: Increasing evidence has shown that p62 plays an important role in tumorigenesis. However, relatively little is known about the association between p62 and tumor invasion and metastasis; in...
View ArticleVS-5584 Inhibits Human Osteosarcoma Cells Growth by Induction of G1- phase...
Background: Activation of the PI3K/mTOR signaling pathway plays a key role in the progression of human osteosarcoma. Studies have confirmed that VS-5584 was a novel inhibitor of the PI3K/mTOR pathway,...
View ArticleNanomedicine: A Promising Avenue for the Development of Effective Therapy for...
Purpose: Breast cancer is the most probable cancer among women. However, the available treatment is based on targeting different stages of breast cancer viz., radiation therapy, hormonal therapy,...
View ArticleTargeting Different Pathways Using Novel Combination Therapy in Triple...
Triple negative breast cancer (TNBC) is one of the most aggressive subtypes of breast cancer accounting for 15-20% of cases and is defined by the lack of hormonal receptors viz., estrogen receptor...
View ArticleStrategic Combination Therapies for Ovarian Cancer
Ovarian cancer remains the leading cause of gynecologic cancer-related deaths among women worldwide. The dismal survival rate is partially due to recurrence after standardized debulking surgery and...
View ArticleTargeted Drug Therapy to Overcome Chemoresistance in Triple-negative Breast...
Triple-negative Breast Cancer (TNBC) is the most aggressive and prevailing breast cancer subtype. The chemotherapeutics used in the treatment of TNBC suffer from chemoresistance, dose-limiting...
View ArticleImmune Checkpoint Inhibitors in Patients with Recurrent Hepatocellular...
Background: Immune checkpoint modulators, such as the programmed death protein-1 (PD-1)/programmed death ligand-1 (PD-L1) inhibitor, cytotoxic T-Lymphocyte-associated antigen 4 (CTLA-4) inhibitor have...
View ArticleCancer Stem Cells with Overexpression of Neuronal Markers Enhance...
Background: Retinoblastoma is a sight and life-threatening embryonal tumor in children. Though chemotherapy is the main mode of therapy, evolving resistance remains a major obstacle in treatment...
View ArticleHOTAIR Competitively Binds MiRNA330 as a Molecular Sponge to Increase the...
Background: HOTAIR, one of the most widely studied long non-coding RNAs in tumors, is closely related to tumor proliferation, migration, invasion and chemoresistance. Objective: Here, we studied the...
View ArticleUSP48 Sustains Chemoresistance and Metastasis in Ovarian Cancer
Background: Ubiquitin specific protease 48 (USP48) is a member of the deubiquitinating enzymes (DUBs) family. However, the function of USP48 in ovarian cancer remains unclear. Objective: The present...
View ArticleNeoadjuvant Chemotherapy Induces the Appearance of New Copy Number...
Background: In this study, we examined the CNA-genetic landscape (CNA – copy number aberration) of breast cancer prior to and following neoadjuvant chemotherapy (NAC) and correlated changes in the...
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