CYP1A1 and CYP2D6 Polymorphisms and Susceptibility to Chronic Myelocytic...
Background: CYP1A1 and CYP2D6 are both xenobiotic metabolizing enzymes belonging to the CYP450 enzyme family. Polymorphisms in these genes vary between individuals, resulting in dissimilar patterns of...
View ArticleSynthesis and Cytotoxic Activity of Azine Derivatives of 6-Hydroxyxanthanodiene
Background: The conjugates of the sesquiterpene lactone of the eremophilane series of 6- hydroxyxanthanodiene with hydrogenated azines (piperidines and piperazines) have been synthesized and identified...
View ArticleEmerging Multi-cancer Regulatory Role of ESRP1: Orchestration of Alternative...
RNA binding proteins (RBPs) associate with nascent and mature RNAs to perform biological functions such as alternative splicing and RNA stability. Having unique RNA recognition binding motifs, RBPs...
View ArticleTargeting MUC15 Protein in Cancer: Molecular Mechanisms and Therapeutic...
MUC15, a member of the mucin family, is a heavily glycosylated transmembrane protein with the primary functions of lubricating surfaces, establishing a selective molecular barrier at the epithelium and...
View ArticleSelinexor (KPT-330), an Oral Selective Inhibitor of Nuclear Export (SINE)...
Background: Selinexor is an oral Selective Inhibitor of Nuclear Export compound that specifically blocks Chromosomal Region Maintenance protein 1. Objective: To evaluate the safety and tolerability of...
View ArticlePrognostic Value of MiRNAs in Patients with Laryngeal Cancer: A Systematic...
Background: Many studies have explored the relationship between the expression level of miRNAs and the prognosis of patients with laryngeal cancer (LC). However, the prognostic value of miRNA in LC...
View ArticleMolecular Dynamics in Esophageal Adenocarcinoma: Who’s in Control?
Esophageal adenocarcinoma (EAC) is one of the fastest-growing cancers in the world. It occurs primarily due to the chronic gastroesophageal reflux disease (GERD), during which the esophageal epithelium...
View ArticleAdvances in Regulating Tumorigenicity and Metastasis of Cancer Through TrkB...
The clinical pathology of various human malignancies is supported by tropomyosin receptor kinase (Trk) B TrkB which is a specific binding receptor of the brain-derived neurotrophic factor (BDNF). TrkB...
View ArticleTargeting NUPR1 for Cancer Treatment: A Risky Endeavor
NUPR1 is a transcription factor that has attracted great attention because of its various roles in cancer. Several studies were carried out to determine its molecular targets and mechanism of action to...
View ArticleRegulation of Breast Cancer Progression by Noncoding RNAs
Background: Breast cancer (BC) is the cardinal cause of cancer-related deaths among women across the globe. Our understanding of the molecular mechanisms underlying BC invasion and metastasis remains...
View ArticleTumor-Induced Metabolism and T Cells Located in Tumor Environment
Several subtypes of T cells are located in a tumor environment, each of which supplies their energy using different metabolic mechanisms. Since the cancer cells require high levels of glucose, the...
View ArticleThe Roles of Alternative Splicing in Tumor-immune Cell Interactions
Alternative splicing (AS) plays a significant role in the hallmarks of cancer and can provide neoantigens for immunotherapy. Here, we summarize recent advances in immune system associated tumor...
View ArticleClinical Outcomes and Safety of Patients Treated with NAb-Paclitaxel Plus...
Background: The phase III MPACT trial demonstrated the superiority of gemcitabine (Gem) combined with Nab-paclitaxel (Nab-P) versus gemcitabine alone in previously untreated patients with metastatic...
View ArticleIdentification of WDFY3 Neoantigens as Prognostic Markers in Longterm...
Background: Neoantigens are newly formed antigens that have not been previously recognized by the immune system. They may arise from altered tumor proteins that form as a result of mutations. Although...
View ArticlePentamethylquercetin Inhibits Hepatocellular Carcinoma Progression and...
Background: Obesity is a significant risk factor for the development of types of cancer. Programmed death 1 and its ligand programmed death-ligand 1 (PD-L1) play a crucial role in tumor immune escape....
View ArticleTargeting Six Hallmarks of Cancer in Ovarian Cancer Therapy
Normal cells must overcome multiple protective mechanisms to develop into cancer cells. Their new capabilities include self-sufficiency in growth signals and insensitivity to antigrowth signals,...
View ArticleAn Overview of Promising Biomarkers in Cancer Screening and Detection
Applications of biomarkers have been proved in oncology screening, diagnosis, predicting response to treatment as well as monitoring the progress of the disease. Considering the crucial role played by...
View ArticleExosome as a Natural Gene Delivery Vector for Cancer Treatment
Background: Current gene therapy vectors such as viral, non-viral, and bacterial vectors, which are used for cancer treatment, but there are certain safety concerns and stability issues of these...
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