ASPM Predicts Poor Clinical Outcome and Promotes Tumorigenesis for Diffuse...
Background: Abnormal spindle-like microcephaly-associated protein (ASPM) has been implicated in the aggressive behavior of several malignant tumors. However, its potential effects on diffuse large...
View ArticleTumor Penetrating Peptide-Functionalized Tenascin-C Antibody for Glioblastoma...
Background: Conjugation to clinical-grade tumor penetrating iRGD peptide is a widely used strategy to improve tumor homing, extravasation, and penetration of cancer drugs and tumor imaging agents. The...
View ArticleTyrosine Kinase Inhibitors (TKIs) in Lung Cancer Treatment: A Comprehensive...
Lung cancer is the leading type of cancer worldwide today. Kinases play a crucial role in mediating the signaling pathways, and it directs to control several necessary cellular processes. Conversely,...
View ArticleThe Activation of Procarcinogens by CYP1A1/1B1 and Related Chemo-Preventive...
CYP1A1 and CYP1B1 are extrahepatic P450 family members involved in the metabolism of procarcinogens, such as PAHs, heterocyclic amines and halogen-containing organic compounds. CYP1A1/1B1 also...
View ArticleC-Myc Signaling Pathway in Treatment and Prevention of Brain Tumors
Brain tumors are responsible for high morbidity and mortality worldwide. Several factors such as the presence of blood-brain barrier (BBB), sensitive location in the brain, and unique biological...
View ArticleOverexpression of RAD50 is the Marker of Poor Prognosis and Drug Resistance...
Background: The prevalence of breast cancer is increasing at an alarming rate and thus demands exploration of the most relevant diagnostic biomarkers. RAD50 is a cancer susceptibility gene that encodes...
View ArticlePotential Role of miRNA in Metastatic Cascade of Triple-Negative Breast Cancer
Triple-negative breast cancer presents an aggressive form of breast cancer subtype, which further lacks efficient treatment strategies and prognostic markers. Genomic heterogeneity in TNBC has led to...
View ArticleMUC Glycoproteins: Potential Biomarkers and Molecular Targets for Cancer Therapy
MUC proteins have great significance as prognostic and diagnostic markers as well as a potential target for therapeutic interventions in most cancers of glandular epithelial origin. These are high...
View ArticleImmunotherapy: A Potential Approach to Targeting Cancer Stem Cells
Tumor recurrence and drug resistance are two of the key factors affecting the prognosis of cancer patients. Cancer stem cells (CSCs) are a group of cells with infinite proliferation potential which are...
View ArticleManagement of Prostate Cancer with Systemic Therapy: A Prostate Cancer Unit...
The scenario of systemic therapy for prostate cancer is rapidly evolving, with new drugs and new treatment options. To update the background knowledge of shared uro-oncologic practice, we reviewed...
View ArticleModulation of Matrix Metalloproteinases by Plant-derived Products
Matrix metalloproteinases (MMPs) are a group of zinc-dependent metalloendopeptidases that are responsible for the degradation, repair, and remodeling of extracellular matrix components. MMPs play an...
View ArticleForkhead-box A3 (FOXA3) Represses Cancer Stemness and Partially Potentiates...
Background: The major challenge to the treatment of advanced colorectal cancer (CRC) is the persistent occurrence of chemoresistance. One of the established etiologies is the existence of cancer...
View ArticleConcomitant Expression of Inhibitory Molecules for T cell Activation Predicts...
Background: Esophageal squamous cell carcinoma (ESCC) is a major subtype of esophageal cancers. The five-year survival rate of ESCC is low, and molecular targets for ESCC treatment and prognosis...
View ArticleTargeted Biological Effect of An Affitoxin Composed of an HPV16E7 Affibody...
Background: High risk type 16 of human papillomavirus (HPV16) is associated with 50% of cervical cancer, for which reliable targeted therapies are lacking. HPV early protein 7 (E7) is an oncoprotein...
View ArticleSelective Antitumor Effect of Shikonin Derived DMAKO-20 on Melanoma through...
Background: CYP1B1 is considered as a valuable target for chemotherapy. It catalyzes the bioactivation of naphthoquinone oximes within certain cancer cell lines. However, the expression level of CYP1B1...
View ArticlePaclitaxel Priming of TRAIL Expressing Mesenchymal Stromal Cells (MSCs-...
Background: Adipose tissue-derived MSCs engineered with the tumor necrosis factor- related apoptosis-inducing ligand protein (MSCs-TRAIL) have significant anticancer activity. MSCs, without any genetic...
View ArticleNovel MicroRNA Binding Site SNPs and the Risk of Clear Cell Renal Cell...
Background: Renal cell carcinoma represents 3% of all adult malignancies. MicroRNAs exhibit specific functions in various biological processes through their interaction with cellular mRNA involved in...
View ArticleMALAT1 as a Versatile Regulator of Cancer: Overview of the Updates from...
The central dogma of molecular biology, has remained a cornerstone of classical molecular biology. However, serendipitously discovered microRNAs (miRNAs) in nematodes paradigmatically shifted our...
View ArticleAcid Ceramidase, a Double-edged Sword in Cancer Aggression: A Minireview
Acid ceramidase (AC), the key enzyme of the ceramide metabolic pathway, hydrolyzes pro-apoptotic ceramide to sphingosine, which is metabolized to mitogenic sphingosine-1-phosphate by the action of...
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