MGMT Epigenetics: The Influence of Gene Body Methylation and Other Insights...
Background: MGMT (O6-methylguanine-DNA methyltransferase) is primarily responsible for limiting the activity of some widely used chemotherapeutic agents, including temozolomide (TMZ) and carmustine...
View ArticleRe-Sensitizing Tumor Cells to Cancer Drugs with Epigenetic Regulators
Cancer drug resistance is a major problem for cancer therapy. While many drugs can be effective in first-line treatments, cancer cells can become resistant due to genetic (mutations and chromosomal...
View ArticleThe Role of RNA Modifications and RNA-modifying Proteins in Cancer Therapy...
The advent of new genome-wide sequencing technologies has uncovered abnormal RNA modifications and RNA editing in a variety of human cancers. The discovery of reversible RNA N6-methyladenosine (RNA:...
View ArticlePROTACs: Promising Approaches for Epigenetic Strategies to Overcome Drug...
Epigenetic modulation of gene expression is essential for tissue-specific development and maintenance in mammalian cells. Disruption of epigenetic processes, and the subsequent alteration of gene...
View ArticleFlavonoids Overcome Drug Resistance to Cancer Chemotherapy by Epigenetically...
Drug resistance is the major reason accounting for the treatment failure in cancer chemotherapy. Dysregulation of the epigenetic machineries is known to induce chemoresistance. It was reported that...
View ArticlemiRNA as Regulators of Prostate Carcinogenesis and Endocrine and Chemoresistance
More therapy options are available for advanced prostate cancer, including novel inhibitors of androgen synthesis, anti-androgens, chemotherapeutics and targeted therapies. Although patients ´ survival...
View ArticleEpigenetic Mechanisms of Therapy Resistance in Diffuse Large B Cell Lymphoma...
Diffuse large B cell lymphoma (DLBCL) is the most common histological subtype of non-Hodgkin B cell lymphoma (NHL), and manifests highly heterogeneous genetic/phenotypic characteristics as well as...
View ArticleEffects of Iron Chelation in Osteosarcoma
Background: Osteosarcoma is an aggressive bone tumor. It represents the principal cause of cancer-associated death in children. Considering the recent findings on the role of iron in cancer, iron...
View ArticleExpression and Clinical Significance of SARS-CoV-2 Human Targets in...
Background: A higher incidence of COVID-19 infection was demonstrated in cancer patients, including lung cancer patients. This study was conducted to get insights into the enhanced frequency of...
View ArticleLncRNAs as Architects in Cancer Biomarkers with Interface of...
Long non-coding RNAs (LncRNAs) epitomize a class of non-coding regulatory RNAs with more than 200 nucleotides, which are long and situated in the nucleus or cytoplasm and rarely encode proteins....
View ArticleThe Mad2-Binding Protein p31comet as a Potential Target for Human Cancer Therapy
The spindle assembly checkpoint (SAC) is a surveillance mechanism that prevents mitotic exit at the metaphase-to-anaphase transition until all chromosomes have established correct bipolar attachment to...
View ArticleCurrent and Future Therapeutic Targets: A Review on Treating Head and Neck...
Head and neck squamous cell carcinoma (HNSCC) continues to be a global public health burden even after a tremendous development in its treatment. It is a heterogeneous cancer of upper aero-digestive...
View ArticleThe Impacts of Non-coding RNAs and N6-Methyladenosine on Cancer: Past,...
N6-methyladenosine (m6A) modifications control multifaceted RNA metabolism and are one of the most extensively distributed modifications on the human transcriptome, including non-coding RNAs (ncRNAs)....
View ArticleAssociation of Polymorphism in Survivin Gene and the Risk of Liver Cancer...
Background: This study aims to investigate the relation between Survivin gene polymorphisms and the risk of Hepatocellular carcinoma (HCC) resulting from hepatitis C infection among the Egyptian...
View ArticleThe Long Non-coding RNA Cytoskeleton Regulator (CYTOR) Sponges microRNA- 206...
Background: The role and mechanism of long non-coding RNA cytoskeleton regulator (CYTOR) in Invasive Pituitary Adenomas (IPA) have not been elucidated previously. Objective: This study aimed to...
View ArticleProtectors of the Mitochondrial Permeability Transition Pore Activated by...
Aim: The study is aimed at examining of action of iron, DOX, and their complex on the Mitochondrial Permeability Transition Pore (MPTP) opening and detecting of possible protectors of MPTP in the...
View ArticleThe Efficacy of Vitamin K, A Member Of Naphthoquinones in the Treatment of...
Background: Redox dysregulation originating from metabolic alterations in cancer cells contributes to their proliferation, invasion, and resistance to therapy. Conversely, these features represent a...
View ArticleAnti-Obesity Medications in Cancer Therapy: A Comprehensive Insight
The interplay between cancer and obesity is multifactorial and complex with the increased risk of cancer development in obese individuals posing a significant threat. Obesity leads to the upregulation...
View ArticleCholangiocarcinoma Therapeutics: An Update
Background: Cholangiocarcinoma (CCA) is the second most common hepatobiliary cancer and associated with a poor prognosis. Only one-third of CCA cases are diagnosed at operable stages. However, a high...
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