Oncolytic Adenovirus H101 Synergizes with Radiation in Cervical Cancer Cells
Background: A major challenge in cervical cancer radiotherapy is tailoring the radiation doses efficiently to eliminate malignant cells and reduce the side effects in normal tissues. Oncolytic...
View ArticleThe Curcumin Analog EF24 is Highly Active Against Chemotherapy- Resistant...
Background: Malignant melanoma (MM) is an aggressive type of skin cancer with a poor prognosis, because MM cells are characterized by unresponsiveness to chemotherapy. Objective: In this study, we...
View ArticleInterrupted Crosstalk between Natural Killer Cells and Anti-epidermal Growth...
Hepatocellular carcinoma (HCC) is a major health problem worldwide. Most patients are diagnosed for the first time at late stages, which leads to very poor prognosis. It is challenging to discover...
View ArticleCross Talk between COVID-19 and Breast Cancer
Cancer patients are more susceptible to COVID-19; however, the prevalence of COVID-19 in different types of cancer is still inconsistent and inconclusive. Here, we delineate the intricate relationship...
View ArticleRediscovering Potential Molecular Targets for Glioma Therapy Through the...
Gliomas are the most common type of malignant brain tumors. Despite significant medical advances, gliomas remain incurable and are associated with high mortality. Although numerous biomarkers of...
View ArticleNanotechnology-enabled Chemodynamic Therapy and Immunotherapy
High-level reactive oxygen species (ROS) have been reported to exert a robust anti-tumor effect by inducing cell apoptosis or necroptosis. Based on the Fenton reaction or Fenton-like reaction, a...
View ArticleNONO-TFE3 Fusion Promotes Aerobic Glycolysis and Angiogenesis by Targeting...
Background: NONO-TFE3 translocation renal cell carcinoma (tRCC), one of the RCCs that are associated with Xp11.2 translocation/TFE3 gene fusion (Xp11.2 tRCCs), involves an X chromosome inversion...
View ArticleMiR-129-5p Promotes Radio-sensitivity of NSCLC Cells by Targeting SOX4 and RUNX1
Background: Dysregulation of microRNAs (miRNAs) figures prominently in the radio- sensitivity of non-small cell lung cancer (NSCLC). MiR-129-5p can block the development of a variety of tumors....
View ArticleNew Insights Toward Nanostructured Drug Delivery of Plant-Derived Polyphenol...
The increasing prevalence of cancer has led to expanding traditional medicine objectives for developing novel drug delivery systems. A wide range of plant-derived polyphenol bioactive substances have...
View ArticleThe Clinical Application of Circulating Tumor Cells and DNAs as Prognostic...
Gastrointestinal (GI) cancer is one of the most common cancers globally. Genetic and epigenetic mechanisms are involved in its pathogenesis. The conventional methods for diagnosis and screening for GI...
View ArticleRole of Exosomes in Breast Cancer Management: Evidence-Based Review
The field of cancer research has massively grown in recent decades, leading to a better understanding of the underlying causes and greatly improving the therapeutic approaches. Breast cancer (BC) is...
View ArticleCrosstalk of Long Non-coding RNAs and EMT: Searching the Missing Pieces of an...
Background: Lung cancer has the first place among cancer-related deaths worldwide and demands novel strategies in the treatment of this life-threatening disorder. The aim of this review is to explore...
View ArticleRole of Aberrant Lipid Metabolism of Cancer Stem Cells in Cancer Progression
Cancer stem cells (CSCs) represent a small population of cancer cells that are able to self-renew and initiate tumors, which undergo epigenetic, epithelial-mesenchymal, immunological, and metabolic...
View ArticleNONO-TFE3 Fusion Promotes Aerobic Glycolysis and Angiogenesis by Targeting...
Background: NONO-TFE3 translocation renal cell carcinoma (tRCC), one of the RCCs that are associated with Xp11.2 translocation/TFE3 gene fusion (Xp11.2 tRCCs), involves an X chromosome inversion...
View ArticleTargeting the HIF-1α/Cav-1 Pathway with a Chicory Extract/Daidzein...
Background: Hepatocellular carcinoma (HCC) is one of the most rapidly growing solid cancers, that is characterized by hypoxia. Hypoxia-inducible factor-1α (HIF-1α) is a transcription factor that...
View ArticleCDK-associated Cullin 1 Promotes Cell Proliferation and Inhibits Cell...
Background: Glioma is the most common intracranial primary tumour of adult humans, and its pathological mechanism and molecular characteristics are still under investigation. CDK-associated cullin 1...
View ArticleMALAT1 Promotes Tumorigenesis and Increases Cellular Sensitivity to Herceptin...
Background: The function of MALAT1, a long non-coding RNAs (lncRNA), in HER2- positive breast cancer remains largely unexplored. Objectives: This study aimed to investigate the effect of MALAT1 on...
View ArticleDDX39B Predicts Poor Survival and Associated with Clinical Benefit of...
Background: Immune checkpoint inhibitors (ICI) have been shown to improve overall survival (OS) in clear cell renal cell carcinoma (ccRCC) patients. However, less than half of the ccRCC patients have...
View ArticleA Molecular Link Between Diabetes and Breast Cancer: Therapeutic Potential of...
Female breast cancer recently surpassed lung cancer and became the most commonly diagnosed cancer worldwide. As per the recent data from WHO, breast cancer accounts for one out of every 8 cancer cases...
View ArticleMetastatic Breast Cancer, Organotropism and Therapeutics: A Review
The final stage of breast cancer involves spreading breast cancer cells to the vital organs like the brain, liver lungs and bones in the process called metastasis. Once the target organ is overtaken by...
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