Mechanisms for the Inhibition of Colon Cancer Cells by Sulforaphane through...
Background: Epigenetic modulations such as histone modifications are becoming increasingly valued for their ability to modify genes without altering the DNA sequence. Many bioactive compounds have been...
View ArticleEpigenetic Regulation of EMT in Non-Small Cell Lung Cancer
Lung cancer remains the most diagnosed cancer in the world, with a high mortality rate and fewer therapeutic options. The most common lung cancer is non-small cell, consisting of adenocarcinoma,...
View ArticleOutlook on Epigenetic Therapeutic Approaches for Treatment of Gastric Cancer
The incidence of gastric cancer has been declining globally in the last decades. Despite the improvements in the diagnostic procedures, most cases are still detected at advanced stages due to lack of...
View ArticleEpigenetics in Clinical Management of Children and Adolescents with Brain Tumors
Central nervous system (CNS) tumors represent the second most prevalent group of cancers in children and adolescents, yet account for the majority of childhood cancer-related deaths and considerable...
View ArticleMultimodal HDAC Inhibitors with Improved Anticancer Activity
Histone deacetylases (HDACs) play a significant role in the proliferation and dissemination of cancer and represent promising epigenetic drug targets. The HDAC inhibitor vorinostat featuring a...
View ArticleTransforming Cancer Epigenetics Using Nutritive Approaches and Noncoding RNAs
Cancer is considered one of the leading causes of death in the United States. Although preventive strategies, early detection, and improved treatment options have been developed, novel targets and...
View ArticleLung Cancer Stem Cells: An Epigenetic Perspective
Lung cancer remains the major cause of human mortality among all the cancer types despite the colossal amount of efforts to prevent the cancer onset and to provide the appropriate cure. Recent reports...
View ArticleIs there a Role for Epigenetic Enhancement of Immunomodulatory Approaches to...
The efficacy of cancer immunotherapy relies on the ability of the host immune system to recognise the cancer as non-self and eliminate it from the body. Whilst this is an extremely fertile area of...
View ArticleTGF-β1 Causes EMT by Regulating N-Acetyl Glucosaminyl Transferases via...
Background: Epithelial to mesenchymal transition (EMT) is a major determinant of cancer metastasis and is closely linked with TGF-β1. Intracellular proteins, including E. Cadherin, N. Cadherin and...
View ArticleOncolytic Virus: Regulatory Aspects from Quality Control to Clinical Studies
Oncolytic viruses, which include both naturally occurring wild-type viruses/attenuated viruses and genetically modified viruses, have recently been developed for use in innovative cancer therapies....
View ArticleOncolytic Virotherapy and Gene Therapy Strategies for Hepatobiliary Cancers
Advanced liver cancers and biliary cancers represent diseases with dismal prognosis because of frequent local invasion and metastasis. Effective therapeutic agents for these cancers have not been...
View ArticleClinical Trials with Oncolytic Measles Virus: Current Status and Future...
Attenuated Edmonston lineage measles virus (MV-Edm) vaccine strains can preferentially infect and lyse a wide variety of cancer cells. Oncolytic MV-Edm derivatives are genetically engineered to express...
View ArticleOncorine, the World First Oncolytic Virus Medicine and its Update in China
The oncolytic viruses now hold a promise of new therapeutic strategy for cancer. Its concept has inspired a wave of commercial research and development activities for the products of this category in...
View ArticleOncolytic Herpes Simplex Virus Vectors Fully Retargeted to Tumor- Associated...
Oncolytic virotherapy is a novel therapeutic modality for malignant diseases that exploits selective viral replication in cancer cells. Herpes simplex virus (HSV) is a promising agent for oncolytic...
View ArticleThe Development of Oncoltyic Adenovirus Therapy in the Past and Future - For...
Pancreatic cancer is an aggressive malignant disease and the efficacy of current treatments for unresectable diseases is quite limited despite recent advances. Gene therapy /virotherapy strategies may...
View ArticleEmergence of Ad-Mediated Combination Therapy Against Cancer: What to Expect?
Novel treatment modalities are rapidly advancing toward clinical use as many malignant cancers still remain incurable. Adenovirus (Ad) in particular has been extensively researched as a promising...
View ArticleCancer-Targeted Oncolytic Adenoviruses for Modulation of the Immune System
Adenovirus is one of the most commonly used vectors for gene therapy and it is the first approved virus-derived drug for treatment of cancer. As an oncolytic agent, it can induce lysis of infected...
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